synthesis of a carbon-14 analogue of n-(aryl-methyl)-3-phenyl-acryl amidine-[carboxy-14c] and its derivatives as nr2b-selective nmda receptor antagonist

Authors

nader saemian

radioisotope section / nuclear science research school, nuclear science and technology research institute, tehran, p.o. box: 11365-3486, iran kameh esmailli

radioisotope section / nuclear science research school, nuclear science and technology research institute, tehran, p.o. box: 11365-3486, iran gholamhossein shirvani

radioisotope section / nuclear science research school, nuclear science and technology research institute, tehran, p.o. box: 11365-3486, iran mohsen javaheri

radioisotope section / nuclear science research school, nuclear science and technology research institute, tehran, p.o. box: 11365-3486, iran omid khalili arjomandi

abstract

four amidine nr2b-selective nmda receptor antagonists, n-( 2-methoxy benzyl) -3-phenyl-acrylamidine, n-[diduterio(2-methoxyphenyl) methyl]-3-phenyl-acrylamidine, n-benzyl-3-phenyl-acryl amidine and n-[diduterio(phenyl)methyl]-3-phenyl-acrylamidine, all fourlabeled with carbon-14 in the 1-position, have been synthesized as part of 5-step sequence fromba14co3.

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Synthesis of a carbon-14 analogue of N-(aryl-methyl)-3-phenyl-acryl amidine-[carboxy-14C] and its derivatives as NR2B-selective NMDA receptor antagonist

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Journal title:

journal of the iranian chemical research

جلد ۳، شماره ۳، صفحات ۲۰۵-۲۰۹

Keywords

[ ' n m d a ' , ' r e c e p t o r ' , ' c a r b o n ' , 1 4 , ' l a b e l i n g ' , ' a m i d i n e s ' ]

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